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Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy.

BMC Med · 2026 · PMC12933958 · PMID 41612317

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Further analysis of peritoneal metastatic tumors showed that Ad5-TriTE treatment led to a reduction in both the number and weight of metastatic nodules compared to PBS-treated mice, although the differences did not reach statistical significance due to intergroup variability.

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