TRKB-based signature identifies high-risk squamous cell carcinoma cases and TRKB blockade reprograms tumor and stromal cells toward suppressive phenotypes.

Although total ERK and AKT protein levels decreased, only a slight trend toward reduced pERK/ERK ratio was noted, and no significant change in the pAKT/AKT ratio was observed (Supplementary Fig. 4 B).

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Different staining patterns were observed among the photoexposed and non-photoexposed sites; however, these differences did not reach statistical significance, likely due to the unequal group sizes (45 vs 10 samples) (Supplementary Fig. 2 A).

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