Computational Characterization of Lymphocyte Topology on Whole Slide Images of Glomerular Diseases.

J Am Soc Nephrol · 2026 · PMC12935365 · PMID 41066167

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showed a trendno p-value reported

Conversely, the average_degree in dense habitats showed a trend of increasing risk of disease progression.

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borderline significanceno p-value reported

Results Unadjusted analysis: 17 features (65%) retained significance after adjustment for standard clinicodemographic variables, Number of K-core in sparse habitat maintained significance (hazard ratio, 1.29; 95% confidence interval, 1.04 to 1.61) even after adjustment for lymphocyte density, and Average Degree in dense habitat had borderline significance (hazard ratio, 1.25; 95% confidence interval, 1.00 to 1.57) after adjustment for interstitial fibrosis.

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