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Genotype-phenotype correlations of fasting C-peptide and lipids in HNF1A-MODY: a single-center series and multi-center cross-sectional analysis in Chinese population.

Front Endocrinol (Lausanne) · 2026 · PMC12935643 · PMID 41767394

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Mutations in the dimerization domain (mean difference = -0.757, p = 0.001) and DNA-binding domain (mean difference = -0.331, p = 0.041) were independently associated with lower FCP levels, while the effect of the transactivation domain did not reach statistical significance ( Table 5A ).

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