Early brain radiotherapy combined with third-generation EGFR-TKIs improves survival in EGFR-mutant NSCLC with synchronous brain metastases: a multi-center retrospective analysis.

Front Oncol · 2026 · PMC12935651 · PMID 41768243

Europe PMC DOI

hedged sentence

0.1770

closest p · 3.5× alpha

0.1770

boldest claim

The sentences

did not reach statistical significanceP = 0.177not close (p > 0.1)

In the HA-WBRT subgroup, a trend favoring ECT was observed, but it did not reach statistical significance for OS (HR 0.71, 95% CI 0.430–1.170; P = 0.177) or iPFS (HR 0.66, 95% CI 0.400–1.090; P = 0.103). 3.7 Treatment-related adverse events The safety profile of the ECT strategy was comparable to that of the SRT strategy.

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