REST-driven upregulation of SFXN3 promotes AML progression via Wnt/β-catenin activation and confers decitabine resistance.

Transl Oncol · 2026 · PMC12936691 · PMID 41720050

Europe PMC DOI

hedged sentence

0.1800

closest p · 3.6× alpha

0.1800

boldest claim

The sentences

did not reach statistical significanceP = 0.180not close (p > 0.1)

Although high SFXN3 expression was also associated with reduced survival in patients aged ≤ 60 years, the difference did not reach statistical significance (HR = 1.56, 95 % CI: 0.81–3.00, P = 0.180), suggesting a stronger prognostic implication of SFXN3 in elderly individuals.

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