Sodium-Glucose Cotransporter-2 Inhibitors and Acute Kidney Injury Risk: A Systematic Review and Meta-Analysis of Randomized Trials.

Kidney Med · 2026 · PMC12937176 · PMID 41767694

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)

The risk of lower limb amputation did not reach statistical significance ( P = 0.07), though the CANVAS trial reported a potential signal.

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