ACE-Dependent Alzheimer's Disease: Blood ACE Phenotyping of the Most Prevalent and Damaging <i>ACE</i> Missense Mutation-Y215C (rs3730025).

After further applying Bonferroni correction to this set of 2388 nominally significant ACE-associated variants at a p -value threshold of 3 × 10 −7 , which was previously found reasonable for exome-sequencing studies of rare variants [ 62 ], we identified 17 variants in 12 genes that reached exome-wide significance— Table 2 .

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