Transcranial Alternating Current Stimulation for Pain: Mixed Evidence and the Path to Precision Neuromodulation.

Brain Sci · 2026 · PMC12938538 · PMID 41750154

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did not reach statistical significanceno p-value reported

[ 39 ] also applied 10 Hz tACS over prefrontal regions and observed autonomic modulation (increased heart rate variability) and a higher proportion of clinical responders in the active condition, although group-level pain reductions did not reach statistical significance.

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