Utility of Circulating Tumor DNA to Assess Tumor Response in Patients with Locally Advanced Rectal Cancer Undergoing Neoadjuvant Therapy.

While ctDNA positivity at the post-NAT pre-surgical timepoint was associated with inferior DFS, this association did not reach statistical significance, likely reflecting the residual tumor heterogeneity prior to resection, variable timing of sampling, and limited sample size at this timepoint.

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