Redox-Related Genetic and Biological Ageing Signals in Rapid Pain Progression of Knee Osteoarthritis: A Hypothesis-Generating Analysis in the Osteoarthritis Initiative.

Antioxidants (Basel) · 2026 · PMC12938837 · PMID 41750646

Europe PMC DOI

hedged sentence

0.0230

closest p · 0.5× alpha

0.0230

boldest claim

The sentences

nominally significantp = 0.023actually significant

In unadjusted analyses, only mtDNA haplogroup H showed a nominally significant over-representation in the rapid pain progressors group (43.4%) compared with non-rapid progressors (39.4%) (OR = 1.179; 95%CI = 1.023–1.359; p = 0.023); however, this association did not remain significant after Bonferroni correction (q-value = 0.115).

also in 7,732 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.