Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences.

Cells · 2026 · PMC12939028 · PMID 41744809

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Despite the absence of direct dietary exposure, F2 offspring from HFD lineages exhibited increased body weight, adiposity, blood pressure, insulin resistance, and dyslipidemia, with a clear trend in metabolic impairment following the cumulative exposure of previous generations (A > B > C > D) [ 175 ].

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