Genetic and Epigenetic Mechanisms in Serrated Adenocarcinomas and Classical Colorectal Carcinomas: An In Silico Study.

Curr Issues Mol Biol · 2026 · PMC12939040 · PMID 41751442

Europe PMC DOI

hedged sentences

0.2500

closest p · 5.0× alpha

0.2500

boldest claim

The sentences

a notable trendp < 0.25not close (p > 0.1)

Specifically, elevated SNW1 expression was significantly correlated with reduced OS ( p < 0.05), while chromatin-related genes H2BC14 , H3C2 , and H1-2 showed a notable trend towards poorer DFS ( p < 0.25).

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did not reach statistical significanceno p-value reported

While the median DFS and OS values were generally shorter in serrated subtypes, this did not reach statistical significance, likely due to the limited number of SAC and partial-SAC cases.

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