TRPV4 Deficiency Shifts Mitochondrial Dynamics Toward a Fragmented Morphology in Primary Microglia.

However, while Mfn1 recruitment per mitochondrial volume did not reduce significantly in Trpv4 KO microglia ( Figure 2 B), Western blot analysis of BMDM lysates revealed a notable trend toward a reduction in total cellular Mfn1 abundance in the absence of TRPV4 ( p = 0.0511, Figure 3 A).

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Interestingly, while the pro-apoptotic stimulus staurosporine (STS) induced a slight upward trend in pDrp1 recruitment, it did not reach statistical significance in our experimental model.

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