Design and Optimization of Thermosensitive Hydrogels Combined with Lipid Nanotechnology for Topical Curcumin Application.

The model was highly significant ( p < 0.0001), with a coefficient of determination R 2 = 0.99 and an adjusted R 2 = 0.98, indicating that the model accurately explains the variability in the response.

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In contrast, the quadratic terms X 1 2 and X 2 2 , as well as the interaction terms X 1 X 2 , X 1 X 3 , and X 2 X 3 , did not reach statistical significance ( p > 0.05).

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