Multi-System Genetic Architecture of Hypermobile Ehlers-Danlos Syndrome: Integrating Machine Learning with Subject-Level Genomic Analysis.

Genes (Basel) · 2026 · PMC12940503 · PMID 41751595

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

nominally significantp < 3.77 × 10 −6actually significant

Genes with p < 0.05 were considered nominally significant; p < 3.77 × 10 −6 achieved genome-wide significance.

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highly significantno p-value reported

A focused view of highly significant genes grouped by functional category ( Figure 2 B) reveals predominance of structural proteins among top associations.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.