Epigenetic Landscape of Female Infertility: An Integrated Bioinformatics Perspective on DNA Methylation, MicroRNAs, and Gene Regulatory Networks Across PCOS, Endometriosis, and Diminished Ovarian Reserve.

We detected 34 nominally significant differentially methylated regions (DMRs) ( p < 0.05, methylation difference > 10%), that included both hyper- and hypo-methylated loci ( Supplementary File S5 ) ( Figure 9 A).

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The Gene Ontology (GO) analysis for Biological Processes showed a highly significant overrepresentation of terms directly linked to immune dysregulation and inflammatory signaling ( Figure 3 C).

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