Restoring Lysosomes in Adipose Tissue Macrophages Mitigates Obesity-Induced Inflammation and Insulin Resistance.

Int J Mol Sci · 2026 · PMC12940729 · PMID 41751892

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an increasing trendno p-value reported

did not reach statistical significanceno p-value reported

In contrast, levels of lysosomal proteases cathepsin L+V (CtsL+V) were significantly reduced, while lysosomal acid lipase (LAL) showed an increasing trend that did not reach statistical significance ( Figure 1 A).

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a decreasing trendno p-value reported

Notably, CD8 + T cells were significantly reduced, whereas CD4 + T cells showed a decreasing trend ( Figure 3 F), suggesting a preferential reduction in pro-inflammatory ATTs.

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