Using HLA-DR3-CBA/J Humanized Mice to Develop a Novel Genetic Model for Autoimmune Thyroiditis.

When directly comparing between mice groups, the levels of IFNg, IL4, IL10 and IL17 produced by stimulated splenocytes in EAT-CBA/J-DR3 mice tended to be higher than those in Control-CBA/J-DR3 mice; however, this difference was only statistically significant for IL4 ( p 0.01 for Tg.2098) and IL10 ( p 0.001 and 0.0005 for Tg and Tg.2098, respectively), but did not reach statistical significance for IFNg ( p = 0.14, and p = 0.16 for Tg and Tg.2098, respectively) and IL17 ( p = 0.09, and p = 0.12 for Tg and Tg.2098, respectively), likely due to the high variability of cytokine levels within each group ( Figure 3 ). 3.3.

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