<i>Kaempferia parviflora</i> Extract Stabilizes Cartilage Homeostasis via TIMP-1-Associated Matrix Modulation in Monosodium Iodoacetate-Induced Rat Osteoarthritis.

In contrast, although MMP1 expression showed a decreasing trend following KPE administration, these changes did not reach statistical significance across the tested doses ( Figure 5 A).

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Systemic inflammatory markers showed differential modulation: significant reductions in serum CRP and COX-2 at medium and high doses, while PGE2 showed a consistent downward trend that did not reach statistical significance.

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