Therapeutic Drug Monitoring of Direct Oral Anticoagulants and Its Association with Clinical Outcomes: A Systematic Review and Meta-Analysis.

Pharmaceuticals (Basel) · 2026 · PMC12943562 · PMID 41754756

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did not reach statistical significanceno p-value reported

These findings align with pharmacologic expectations that sub-therapeutic exposure may diminish anticoagulant protection, though the observed trend did not reach statistical significance.

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