Combined Intraperitoneal and Systemic Chemotherapy for Peritoneal Metastases: Drug Delivery Concepts, Pharmacokinetics, and Clinical Applications: A Narrative Review.

Pharmaceutics · 2026 · PMC12943871 · PMID 41754921

Europe PMC DOI

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In a large French multicenter study of 523 patients, complete CRS followed by HIPEC using MMC or oxaliplatin achieved a median OS of 30.1 months and a 5-year survival rate of 27% [ 92 ] Complete cytoreduction had a highly significant impact on prognosis ( p < 0.001), whereas neither histologic grade nor the presence of synchronous liver metastasis adversely affected outcomes when complete resection was achieved.

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near-significantp = 0.05actually significant

22 months, p = 0.01), and OS showed a near-significant improvement (63 months vs. 52 months, p = 0.05).

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