Span Value as a Critical Quality Attribute for PLGA Microspheres: Controlling Burst Release and Enhancing Therapeutic Efficacy via Wet Sieving.

Pharmaceutics · 2026 · PMC12944294 · PMID 41754922

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an increasing trendno p-value reported

Area Under the Curve (AUC): The AUC values in the 28–40 μm group exhibited an increasing trend.

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a clear trendno p-value reported

The similarity factor (f2) analysis indicated that the profiles of the three groups were similar (f2 > 50), but with a clear trend.

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