Unconventional Lysine-Type Lipid Assemblies Enable Efficient Antisense Oligonucleotide Delivery with Distinct Structural Features.

Pharmaceutics · 2026 · PMC12944301 · PMID 41754970

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a clear trendno p-value reported

Collectively, the screening of cytotoxicity and formulation stability pointed to a clear trend that lysine-type lipids with either a 3-hydrocarbon spacer (K3), such as K3C14 and K3C16, or C14 dual fatty acid tails, such as K3C14, K5C14 and K7C14, are essential for achieving lower cytotoxicity and higher stability.

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