Barely Significant
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Development and Evaluation of Curcumin-Loaded Mucoadhesive Buccal Films Using Green Deep Eutectic Solvents via Design of Experiments.

Pharmaceutics · 2026 · PMC12944374 · PMID 41754987

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an increasing trendno p-value reported
An increasing trend in wound closure was observed with increasing formulation concentration within the tested range; however, this was not intended as a clinical dose–response analysis.

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a negative trendno p-value reported
Kollicoat ® IR (X 2 ) displayed a negative trend in both linear and quadratic terms, although these effects were not statistically significant.

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highly significantno p-value reported
Thickness The DoE analysis of film thickness identified the linear model as the most appropriate fit, supported by a highly significant model p -value (<0.0001), a strong Adequate Precision value (13.54), and good agreement between the adjusted (0.6847) and predicted (0.5607) R 2 values.

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