Development and Validation of a UPLC-MS/MS Method for the Quantification of Amantadine in Rat Plasma: Application to a Pharmacokinetic Study Under High-Altitude Hypoxia and Mechanistic Insights.

Pharmaceuticals (Basel) · 2026 · PMC12944594 · PMID 41754852

Europe PMC DOI

hedged sentence

0.1130

closest p · 2.3× alpha

0.1130

boldest claim

The sentences

showed a trendp = 0.113not close (p > 0.1)

The apparent volume of distribution (Vz/F) showed a trend toward an increase (58% increase, p = 0.113) in the HAE group. 3.

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