AHR-CYP1A1 Axis Perturbation and Necroptosis in 1,2-Dichloroethane Hepatotoxicity: Elucidation by an Integrated Network Toxicology and In Vitro Validation.

Subsequent Dunnett’s multiple comparisons test showed that while a marked and statistically significant decrease was observed after 24 h of 1,2-DCE treatment compared to the control ( p < 0.0001), the reductions at 3 h time points, though showing a downward trend, did not reach statistical significance ( Figure 2 B). 3.3.

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