Barely Significant
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Comparison of Immune Cell Transfection by Different Vaccine Vectors After Intradermal Injection.

Vaccines (Basel) · 2026 · PMC12945243 · PMID 41746105

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did not reach statistical significanceno p-value reported
Naked DNA and DNA-LNP mediated detectable GFP activation in the skin and draining lymph node in some mice, but this activity was low and did not reach statistical significance when compared to PBS-treated animals. mRNA-LNPs and Ad both mediated significant Cre delivery in CD45 + , CD3 + , CD11b + , and CD207 + immune cells in the skin and in the lymph node, with adenovirus mediating consistently higher levels of expression in all of the tested cells.

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