Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues.

Nat Metab · 2026 · PMC12945685 · PMID 41593238

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nominally significantno p-value reported

Among the genes tested in at least two tissues, 75% (14,304 out of 19,020) show nominally significant heterogeneity.

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highly significantno p-value reported

This is the case for FTO , for example, which is highly significant in skeletal muscle eQTL MR ( q = 4.62 × 10 −106 ), but not confirmed by colocalization (PPH4 = 0.16).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.