The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real-world data.

Alzheimers Dement · 2026 · PMC12945722 · PMID 41748529

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showed a trendno p-value reported

As shown in Table 3 , participants with high non‐ APOE PRS (above the second tertile) showed a trend toward benefit from statins use (aRD: −5.9‰, 95% CI: −8.1‰ to 1.2‰), while those with low non‐ APOE PRS showed no benefit (aRD: 0.8‰, 95% CI: −1.5‰ to 3.8‰).

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