Central Irisin Administration Attenuates Hypothalamic TLR4/MyD88-Mediated Neuroinflammatory Signaling in Diet-Induced Obese Mice.

Both cytokines were elevated in the HFD-Veh group; irisin treatment significantly reduced Il6 mRNA levels, whereas Il1b showed a visual reduction that did not reach statistical significance, likely due to high variability in the non-parametric analysis (Fig. 5 B).

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