TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons.

At 1 and 2 years of age, no differences in motor neuron size were observed in our models, although we did observe a slight trend of tardbp A379T/A379T and tardbp G347C/G347C motor neurons possessing smaller cell body sizes when compared to wild‐type motor neurons, although this did not reach significance.

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In these zebrafish, tardbp A379T/− showed a trend in lower Tdp‐43 expression levels and expression was significantly reduced in tardbp G347C/− with concomitant increased expression of Tdp‐43‐like V1.

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