Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population.

Alzheimers Dement · 2026 · PMC12946819 · PMID 41755704

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Meta‐analyses with genetically‐matched AoU participants yielded three (two novel) genome‐wide significant AD‐associated loci based on rare lead variants: rs374043832 ( RGS6/PSEN1 ), rs192423465 ( ASPSCR1 ), and rs935208076 ( GDAP2 ), which were nominally significant in AoU sub‐cohorts.

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