Barely Significant
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Polygenic risk score predicts presence of subclinical atherosclerosis in first-degree relatives of patients with premature coronary artery disease.

Am J Prev Cardiol · 2026 · PMC12946890 · PMID 41767442

Europe PMCDOI
1
hedged sentence
0.4000
closest p · 8.0× alpha
0.4000
boldest claim

The sentences

did not reach statistical significancep = 0.4not close (p > 0.1)
The addition of the PRS CAD to FRS led to a numerical increase in C-index for identifying patients with significant atherosclerosis from 0.77 (95 % CI 0.68–0.85) to 0.79 (95 % CI 0.71–0.87), which did not reach statistical significance ( p = 0.4).

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