Investigating the dynamic association of multiple risk factors on cognitive impairment in older people: a retrospective cohort study in Baisha Town, Hepu County, China.

BMC Geriatr · 2026 · PMC12947504 · PMID 41620655

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did not reach statistical significanceno p-value reported

Further RCS analysis suggested a potential nonlinear trend between TC/LDL-C and cognitive impairment, but this did not reach statistical significance.

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a marginal trendno p-value reported

The hypertension × time interaction was negative in the larger samples but was not consistently retained, while the BMI × time interaction trended positive but remained statistically non-significant across samples, despite a marginal trend.

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