Evaluation of six clinical prognostic scores in NSCLC patients undergoing first line chemoimmunotherapy.

Front Immunol · 2026 · PMC12953529 · PMID 41782884

Europe PMC DOI

hedged sentences

0.2200

closest p · 4.4× alpha

0.2200

boldest claim

The sentences

did not reach statistical significanceP = 0.220not close (p > 0.1)

In contrast, liver metastasis did not reach statistical significance in the multivariate analysis in this study (P = 0.220).

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marginal significanceno p-value reported

For PFS, the MDACC+NLR score showed a marginal significance after FDR correction (Q = 0.054).

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borderline significantno p-value reported

The MDACC+NLR score showed particular strength in short-term outcome prediction, with favorable 1-year AUCs for both OS and PFS and a borderline significant association with PFS after multiple testing adjustment, suggesting that this model may be especially useful in clinical scenarios or trial designs focused on early events such as rapid disease progression.

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