Finally, tolerogenic CCR7 + CD69 +/– CD103 +/– NK cells were significantly reduced, while transitional and cytotoxic NK cells showed a trend toward increased presence in the colorectal tissue after galunisertib ( Figure 7D ).
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Single-cell capture of on-ART SIV transcription reveals TGF-β-mediated metabolic control of viral latency.
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Hence, we focused on highly significant uncorrected DEGs that, together with GSEA, suggested that on-ART viral transcription is associated with a quiescent/exhausted phenotype.