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Glycoengineering CAR-T cells to overcome galectin-3-mediated immunosuppression.

Front Immunol · 2026 · PMC12956802 · PMID 41789075

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Although Gal-1, Gal-3, and Gal-9 transcripts trended higher in early-failure patients, these differences did not reach statistical significance ( Supplementary Figure 1b-d ), suggesting that galectin expression alone may not stratify clinical outcomes.

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