Intraoperative Methadone for Post-craniotomy Pain Control: A Matched Cohort Exploratory Framework Study.

Cureus · 2026 · PMC12957433 · PMID 41788092

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did not reach statistical significanceno p-value reported

Given the small sample, between-group differences did not reach statistical significance at any timepoint; however, the direction of effect favored methadone at 48 hours for both outcomes.

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