Comparing the Efficacy and Safety of Endovascular Therapy Versus Best Medical Treatment in Acute Ischemic Stroke Patients With Distal Medium Vessel Occlusion: A Systematic Review and Meta-Analysis.

also observed a numerical increase in sICH with EVT, though it did not reach statistical significance in their smaller sample. 13 Notably, a meta-analysis by Chen et al. focusing on EVT in large LVO among patients with mild stroke also found a higher incidence of sICH in the EVT group compared to those treated with medical management, suggesting that lower stroke severity may be associated with a less favorable risk-benefit profile for EVT. 68 Taken together, the available evidence indicates that EVT for DMVO does increase the risk of symptomatic bleeding, and this risk should be carefully weighed against the uncertain clinical benefit.

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