Unilateral Microelectrode Recording-Guided Pallidotomy in Advanced Parkinson's Disease: Clinical and Neuropsychological Outcomes in a Guatemalan Cohort.

Rev Neurol · 2026 · PMC12958054 · PMID 41761997

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0840

boldest claim

The sentences

highly significantp < 0.0001actually significant

Paired t -tests confirmed a highly significant reduction in motor scores ( t = 6.19, p < 0.0001; mean change –26.3 points, 95% confidence intervals (CI) –34.7 to –18.0).

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a trend toward significancep = 0.084so close (0.05 < p ≤ 0.1)

Mean rigidity scores decreased slightly (–0.50 points), bradykinesia showed a moderate reduction (–0.54 points, dz = –0.55) with a trend toward significance ( p = 0.084), and rest tremor was reduced by half (–0.75 points, dz = –0.49), though without reaching statistical significance.

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did not reach statistical significanceno p-value reported

These findings suggest that unilateral pallidotomy may extend beyond purely contralateral effects, although the ipsilateral and axial improvements were of smaller magnitude and did not reach statistical significance.

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