The role of preoperative antibiotic prophylaxis in the relationship between intestinal colonization and post-ERCP biliary tract infection: a prospective cohort study.

Antimicrob Resist Infect Control · 2026 · PMC12958688 · PMID 41634842

Europe PMC DOI

hedged sentence

0.1320

closest p · 2.6× alpha

0.1320

boldest claim

The sentences

did not reach statistical significanceP = 0.132not close (p > 0.1)

The natural indirect effect mediated through antibiotic prophylaxis also did not reach statistical significance and suggested a possible, though imprecise, protective pathway (HR = 0.93; 95% CI 0.85–1.02; P = 0.132), accounting for approximately 21% of the observed attenuation in the total effect.

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