The current state of polygenic scores for the development of lung cancer: a systematic review and validation in UK Biobank.

Br J Cancer · 2026 · PMC12960659 · PMID 41507563

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showed a trendno p-value reported

However, a small number of PGS ( n = 8) showed a trend in the other direction, in particular, we note, Dai2019 [ 29 ] (the C-index in individuals with no history of tobacco use is 0.566 [0.540–0.592] compared to 0.527 [0.512–0.542] in individuals with active tobacco use), Qin2022 [ 52 ] (0.562 [0.536–0.588] and 0.536 [0.521–0.551] and Zhu2023a [ 42 ] (0.561 [0.535–0.587] and 0.521 [0.506–0.535]).

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