Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis.

We observed a decrease of AA5HT (in the duodenum), EPA5HT (in the colon), and DHA5HT (in all tissues analysed except the colon, where, however, a strong trend was observed), which are known to inhibit FAAH, the main hydrolytic enzymes of unsaturated NAEs, and to antagonize TRPV1 channels (Table 1 ).

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