Uptake and Biotransformation Govern the Toxicity of Reactive Acrylamides in an <i>In Vivo</i> Zebrafish Embryo Model: Implications for NAM-Based Hazard Assessment.

Environ Sci Technol · 2026 · PMC12961924 · PMID 41707120

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a negative trendno p-value reported

Our finding of a negative trend between normalized glutathione and mercapturic acid adduct peak areas and log(1/LC 50 ) values is in line with mechanistic data from Komoike et al., where acrylamide exposure induced upregulation of gstp1 expression and oxidative stress response.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Uptake and Biotransformation Govern the Toxicity of Reactive Acrylamides in an &lt;i&gt;In Vivo&lt;/i&gt; Zebrafish Embryo Model: Implications for NAM-Based Hazard Assessment.

The sentences

Uptake and Biotransformation Govern the Toxicity of Reactive Acrylamides in an <i>In Vivo</i> Zebrafish Embryo Model: Implications for NAM-Based Hazard Assessment.