Functional characterization of BAP1 mutations in genome edited cholangiocarcinoma organoids: Role in cell death and drug responses.

iScience · 2026 · PMC12962116 · PMID 41797921

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did not reach statistical significanceno p-value reported

In contrast, CCAO BAP1-Mut organoids showed only 3% pMLKL-positive cells, and this difference did not reach statistical significance, suggesting impaired necroptotic activation in the context of BAP1 mutation ( Figures 2 E and 2G).

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