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A missense mutation in acyl-CoA synthetase ACSL4 reveals essential residues for catalytic activity in ferroptosis.

J Biol Chem · 2026 · PMC12962168 · PMID 41651426

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Consistent with the cell viability, WT-expressing clone B showed a tendency toward increased lipid peroxidation compared with T237A-expressing clone B and empty vector controls, although these differences did not reach statistical significance ( Fig. 7 C ).

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