Comprehensive Pathophysiology Repository for PBPK Modeling in Liver Cirrhosis: Quantifying Continuous Disease Progression and Population Variability.

CPT Pharmacometrics Syst Pharmacol · 2026 · PMC12962396 · PMID 41717827

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a slight trendno p-value reported

For Child‐Pugh C patients there is a slight trend of underestimating the effect of cirrhosis on c max . t half is described well for all Child‐Pugh classes, with only omeprazole values being slightly overpredicted.

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a clear trendno p-value reported

The renal blood flow shows a clear trend of decreasing rates with increasing Child‐Pugh score (Figure S7 ).

also in 19,460 other papers

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