Direct comparison of three herpes simplex virus-2 vaccine candidates using peripheral or mucosal routes of vaccination.

Intravaginal vaccination with replication-competent or replication-defective vaccines induces low levels of serum neutralizing antibodies Mice vaccinated with gD27 had higher levels of serum neutralizing antibody than animals that received ΔgD-2 or dl 5–29, although the differences did not reach statistical significance ( Fig. 6 , Table 1 ).

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P values falling within the range of 0.05 to 0.05/N were interpreted as indicative of a trend towards significance since if N > 1, 0.05/N is smaller than 0.05. 3.

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