Factors associated with longitudinal MDS-UPDRS III score trajectories in early-stage Parkinson's disease.

Specifically, lower albumin levels were associated with an increased likelihood of being in the Moderate Progression group (missing data exclusion: OR = 0.95, 95% CI: 0.91–0.99, p = 0.025; 10-year follow-up: OR = 0.95, 95% CI: 0.91–0.99, p = 0.016) and a significant trend towards decreased likelihood in the Rapid Progression group (missing data exclusion: OR = 0.87, 95% CI: 0.78–0.96, p = 0.007; 10-year follow-up: OR = 0.9, 95% CI: 0.82–0.98, p = 0.022) compared to the Slow Progression group.

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For BMI, the association with the Rapid Progression group was inconsistent, showing no significance with missing data exclusion (OR = 1.31, 95% CI: 0.94–1.8, p = 0.106), but borderline significance in the 10-year follow-up (OR = 1.33, 95% CI: 1–1.76, p = 0.046), whereas the association with the Moderate Progression group remained robust (missing data exclusion: OR = 1.22, 95% CI: 1.01–1.47, p = 0.038; 10-year follow-up: OR = 1.21, 95% CI: 1.02–1.43, p = 0.028).

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